1 | Gillian McHugo

Common protein-coding variants influence the racing phenotype in galloping racehorse breeds

Abstract Selection for system-wide morphological, physiological, and metabolic adaptations has led to extreme athletic phenotypes among geographically diverse horse breeds. Here, we identify genes contributing to exercise adaptation in racehorses by applying genomics approaches for racing performance, an end-point athletic phenotype.

Haige Han, Beatrice A. McGivney, Lucy Allen, Dongyi Bai, Leanne R. Corduff, Gantulga Davaakhuu, Jargalsaikhan Davaasambuu, Dulguun Dorjgotov, Thomas J. Hall, Andrew J. Hemmings, Amy R. Holtby, Tuyatsetseg Jambal, Badarch Jargalsaikhan, Uyasakh Jargalsaikhan, Naveen K. Kadri, David E. MacHugh, Hubert Pausch, Carol Readhead, David Warburton, Manglai Dugarjaviin, Emmeline W. Hill

2022

High-resolution transcriptomics of bovine purified protein derivative-stimulated peripheral blood from cattle infected with 𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘣𝘰𝘷𝘪𝘴 across an experimental time course

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Carolina N. Correia, Gillian P. McHugo, John A. Browne, Kirsten E. McLoughlin, Nicolas C. Nalpas, David A. Magee, Adam O. Whelan, Bernardo Villarreal-Ramos, H. Martin Vordermeier, Eamonn Gormley, Stephen V. Gordon, David E. MacHugh

Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations

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James A. Ward, Gillian P. McHugo, Michael J. Dover, Thomas J. Hall, Said Ismael Ng'ang'a, Tad S. Sonstegard, Daniel G. Bradley, Laurent A.F. Frantz, Michael Salter-Townshend, David E. MacHugh

Mycobacterial infection of precision-cut lung slices reveals type 1 interferon pathway is locally induced by 𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘣𝘰𝘷𝘪𝘴 but not 𝘔. 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 in a cattle breed

Abstract Tuberculosis exacts a terrible toll on human and animal health. While Mycobacterium tuberculosis (Mtb) is restricted to humans, Mycobacterium bovis (Mb) is present in a large range of mammalian hosts.

Aude Remot, Florence Carreras, Anthony Coupé, Émilie Doz-Deblauwe, Maria L. Boschiroli, John A. Browne, Quentin Marquant, Delphyne Descamps, Fabienne Archer, Abraham Aseffa, Pierre Germon, Stephen V. Gordon, Nathalie Winter

2021

Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria

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Thomas J. Hall, Michael P. Mullen, Gillian P. McHugo, Kate E. Killick, Siobhán C. Ring, Donagh P. Berry, Carolina N. Correia, John A. Browne, Stephen V. Gordon, David E. MacHugh

Identification of novel molecular markers of mastitis caused by 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴 using gene expression profiling in two consecutive generations of Chinese Holstein dairy cattle

Abstract Background Mastitis in dairy cows caused by Staphylococcus aureus is a major problem hindering economic growth in dairy farms worldwide. It is difficult to prevent or eliminate due to its asymptomatic nature and long persistence of infection.

Di Wang, Lei Liu, Serafino M. A. Augustino, Tao Duan, Thomas J. Hall, David E. MacHugh, Jinhuan Dou, Yi Zhang, Yachun Wang, Ying Yu

2020

Unlocking the origins and biology of domestic animals using ancient DNA and paleogenomics

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Gillian P. McHugo, Michael J. Dover, David E. MacHugh

A population genomics analysis of the native Irish Galway sheep breed

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Gillian P. McHugo, Sam Browett, Imtiaz A. S. Randhawa, Dawn J. Howard, Michael P. Mullen, Ian W. Richardson, Stephen D. E. Park, David A. Magee, Erik Scraggs, Michael J. Dover, Carolina N. Correia, James P. Hanrahan, David E. MacHugh

Genomic characterisation of the indigenous Irish Kerry cattle breed

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Sam Browett, Gillian McHugo, Ian W. Richardson, David A. Magee, Stephen D. E. Park, Alan G. Fahey, John F. Kearney, Carolina N. Correia, Imtiaz A. S. Randhawa, David E. MacHugh