1 | Gillian McHugo

Functional genomics of trypanotolerant and trypanosusceptible cattle infected with 𝘛𝘳𝘺𝘱𝘢𝘯𝘰𝘴𝘰𝘮𝘢 𝘤𝘰𝘯𝘨𝘰𝘭𝘦𝘯𝘴𝘦 across multiple time points and tissues

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Gillian P. McHugo, James A. Ward, John A. Browne, Grace M. O'Gorman, Kieran G. Meade, Emmeline W. Hill, Thomas J. Hall, David E. MacHugh

Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle

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John F. O'Grady, Gillian P. McHugo, James A. Ward, Thomas J. Hall, Sarah L. Faherty O'Donnell, Carolina N. Correia, John A. Browne, Michael McDonald, Eamonn Gormley, Valentina Riggio, James G. D. Prendergast, Emily L. Clark, Hubert Pausch, Kieran G. Meade, Isobel C. Gormley, Stephen V. Gordon, David E. MacHugh

Genome-wide local ancestry and the functional consequences of admixture in African and European cattle populations

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Gillian P. McHugo, James A. Ward, Said Ismael Ng'ang'a, Laurent A. F. Frantz, Michael Salter-Townshend, Emmeline W. Hill, Grace M. O'Gorman, Kieran G. Meade, Thomas J. Hall, David E. MacHugh

Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens

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Thomas J. Hall, Gillian P. McHugo, Michael P. Mullen, James A. Ward, Kate E. Killick, John A. Browne, Stephen V. Gordon, David E. MacHugh

Unveiling the role of endoplasmic reticulum stress pathways in canine demodicosis

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Pamela A. Kelly, Gillian P. McHugo, Caitriona Scaife, Susan Peters, M. Lynn Stevenson, Jennifer S. McKay, David E. MacHugh, Irene Lara-Saez, Rory Breathnach

Transcriptomics analysis of the bovine endometrium during the perioestrus period

Abstract During the oestrous cycle, the bovine endometrium undergoes morphological and functional changes, which are regulated by alterations in the levels of oestrogen and progesterone and consequent changes in gene expression.

Mohammed A. Alfattah, Carolina N. Correia, John A. Browne, Paul A. McGettigan, Katarzyna Pluta, Stephen D. Carrington, David E. MacHugh, Jane A. Irwin

2024

Genomic insights into the population history and adaptive traits of Latin American Criollo cattle

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James A. Ward, Said I. Ng’ang’a, Imtiaz A. S. Randhawa, Gillian P. McHugo, John F. O'Grady, Julio M. Flórez, John A. Browne, Ana M. Pérez O'Brien, Antonio J. Landaeta-Hernández, José F. Garcia, Tad S. Sonstegard, Laurent A. F. Frantz, Michael Salter-Townshend, David E. MacHugh

Preferential differential gene expression within the WC1.1⁺ γδ T cell compartment in cattle naturally infected with 𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘣𝘰𝘷𝘪𝘴

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Sajad A. Bhat, Mahmoud Elnaggar, Thomas J. Hall, Gillian P. McHugo, Cian Reid, David E. MacHugh, Kieran G. Meade

Common protein-coding variants influence the racing phenotype in galloping racehorse breeds

Abstract Selection for system-wide morphological, physiological, and metabolic adaptations has led to extreme athletic phenotypes among geographically diverse horse breeds. Here, we identify genes contributing to exercise adaptation in racehorses by applying genomics approaches for racing performance, an end-point athletic phenotype.

Haige Han, Beatrice A. McGivney, Lucy Allen, Dongyi Bai, Leanne R. Corduff, Gantulga Davaakhuu, Jargalsaikhan Davaasambuu, Dulguun Dorjgotov, Thomas J. Hall, Andrew J. Hemmings, Amy R. Holtby, Tuyatsetseg Jambal, Badarch Jargalsaikhan, Uyasakh Jargalsaikhan, Naveen K. Kadri, David E. MacHugh, Hubert Pausch, Carol Readhead, David Warburton, Manglai Dugarjaviin, Emmeline W. Hill

2022

High-resolution transcriptomics of bovine purified protein derivative-stimulated peripheral blood from cattle infected with 𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘣𝘰𝘷𝘪𝘴 across an experimental time course

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Carolina N. Correia, Gillian P. McHugo, John A. Browne, Kirsten E. McLoughlin, Nicolas C. Nalpas, David A. Magee, Adam O. Whelan, Bernardo Villarreal-Ramos, H. Martin Vordermeier, Eamonn Gormley, Stephen V. Gordon, David E. MacHugh